Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats
نویسندگان
چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
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15 صفحه اولRenin-angiotensin system in spontaneously hypertensive rats.
Plasma and kidney renin activities (PRA, KRA) were determined in male spontaneously hypertensive rats (SHR), the inbred strain of F27-30. Blood samples of 0.5 ml for PRA determination were obtained through a cannula inserted into the abdominal aorta without anesthesia to minimize renin release from the kidney. The PRA was 30 wk. The KRA of SHR at age 10, 20, and 30 wk was also lower, confirming...
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Tissue renin-angiotensin systems are known to behave differently from the circulating renin-angiotensin system (RAS). It has already been proposed that not only the circulating RAS, but also RAS localized in the cardiac tissue plays an important role in the heart failure. The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system in h...
متن کاملgarlic powder effect on plasma renin activity, and cardiovascular effects of intravenous angiotensin i and angiotensin ii in normotensive and hypertensive male rats
conclusions garlic powder consumption can reduce blood pressure, yet in this model, it did not have an effect on the interaction between renin angiotensin system and nitric oxide inhibition. results at the beginning and at the end of experiments, systolic blood pressure was higher in the hypertensive groups than the normotensive group. however, at the end of the study, diastolic blood pressure ...
متن کاملRenin-angiotensin system in two genetically normotensive strains of Lyon rats.
Compared to the Lyon normotensive (LN) controls, adult Lyon hypertensive rats (LH) exhibit a renin-angiotensin system (RAS) dependent hypertension despite a low renin secretion. This discrepancy could be explained by the elevated slow pressor response to angiotensin II (AII) found in LH rats compared to LN controls. To evaluate more precisely the pathophysiological importance of this increased ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Hypertension
سال: 2008
ISSN: 1933-1711
DOI: 10.1016/j.jash.2007.10.005